yearly rate of change by linear regression gives the slope of the least-squares line of best fit to a graph of attribute values against elapsed years. For example, given the following case fragment:

           14 Sep 08    30 Sep 08    05 Jan 09    07 Apr 09    01 Jul 09    10 Jul 09    13 Oct 09
ABC           71.2         72.09        70.67        90.29                     114.26       246.20

The following condition could be added:

yearly rate of change of PSA by linear regression > 100